File:1756-8935-5-4-3-l.jpg
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Summary[edit]
| Description |
English: Mammalian double-strand break (DSB) repair.
Non-homologous end joining (NHEJ) and homologous recombination (HR) in mammals during DNA double-strand break. Figure from article Hannes Lans, Jurgen A. Marteijn & Wim Vermeulen (2012). "ATP-dependent chromatin remodeling in the DNA-damage response". Epigenetics & chromatin 5: 4. DOI:10.1186/1756-8935-5-4. PMID 22289628. License info.Українська: Репарація дволанцюгових розривів ДНК у ссавців.
Негомологічне з'єднання кінців (Non-homologous end joining, NHEJ) та гомологічна рекомбінація (homologous recombination, HR). При гомологічній рекомбінації для зшивання ДНК розриву використовується матриця цілої молекули ДНК (синя), таким чином можна точно скопіювати послідовність нуклеотидів і відновити молекулу ДНК. Тоді як негомологічне з'єднання кінців призводить або к делеціям або к інсерціям нуклеотидів. Ілюстрація зі статті Hannes Lans, Jurgen A. Marteijn & Wim Vermeulen (2012). "ATP-dependent chromatin remodeling in the DNA-damage response". Epigenetics & chromatin 5: 4. DOI:10.1186/1756-8935-5-4. PMID 22289628. |
| Date | |
| Source | BioMed Central |
| Author | Hannes Lans, Jurgen A Marteijn and Wim Vermeulen |
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License info of Epigenetics & Chromatin.
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